Effect of a bacteriocin-producing <i>Streptococcus salivarius</i> on the pathogen <i>Fusobacterium nucleatum</i> in a model of the human distal colon
Garreth W. Lawrence, Niamh McCarthy, Calum J. Walsh, Tais M. Kunyoshi, Elaine M. Lawton, Paula M. O’Connor, Máire Begley, Paul D. Cotter, Caitriona M. Guinane
Abstract
DPC6993 on the surrounding microbiota. Overall, this study highlights the ability of a natural gut bacterium to target a bacterial pathogen associated with CRC. The specific targeting of CRC-associated pathogens by biotherapeutics may ultimately reduce the risk of CRC development and positively impact CRC outcomes.
Topics & Concepts
Fusobacterium nucleatumMicrobiologyLactobacillus salivariusBiologyBacteriocinStreptococcus salivariusAntimicrobialPathogenFusobacteriumStreptococcusBacteriaLactobacillusGeneticsBacteroidesPorphyromonas gingivalisGut microbiota and healthProbiotics and Fermented FoodsOral microbiology and periodontitis research