<i>In vitro</i>and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-M<sup>Pro</sup>inhibitors
Ateyatallah Aljuhani, Hany E. A. Ahmed, Saleh Ihmaid, Abdelsattar M. Omar, Sultan S. Althagfan, Yaser M. Alahmadi, Iqrar Ahmad, Harun Patel, Sahar Ahmed, Mohannad A. Almikhlafi, Ahmed M. El‐Agrody, Mohamed F. Zayed, Safaa A. Turkistani, Shorouk H. Abulkhair, Mohammed Almaghrabi, Samir A. Salama, Ahmed A. Al‐Karmalawy, Hamada S. Abulkhair
Abstract
assay. These results suggested that compounds 25 and 29 merit further investigations as promising drug candidates for the management of SARS-CoV-2.
Topics & Concepts
Vero cellIn vitroDocking (animal)CytotoxicityProteaseChemistryIC50CarboxamideStereochemistryBiochemistryEnzymeMedicineNursingComputational Drug Discovery MethodsSynthesis and biological activityCancer therapeutics and mechanisms