In vivo oncolytic activity of non-virulent newcastle disease virus Iraqi strain against mouse mammary adenocarcinoma
Shatha M. Ali, Bahaa A. Lafta, Ahmed Majeed Al-Shammari, Hasnain S. Salih
Abstract
Newcastle disease virus (NDV) is promising antitumor agent that triggers immediate cytolysis of the tumor, apoptosis and activation of the immune system. This study was aimed at testing the antiangiogenic NDV Performance on a model of breast cancer. NDV has been studied against mammalian adenocarcinoma AN3 transplanted into syngeneic immunocompetent mice through intratumoral injection to determine the antitumor activity of NDV in vivo. Histopathological sections for the treated tumor mass demonstrated proliferation of granulation tissue with substantial necrosis region. This study indicated the role of Iraqi strain NDV in reducing the volume of solid tumor when compared with untreated group which is confirmed feature that make NDV Iraqi strain as anti-tumor agents.