Electrospun Nanofibrous Architectures of Thrombin-Loaded Poly(ethylene oxide) for Faster <i>in Vivo</i> Wound Clotting
Larissa Giorgetti Mendes, Filipe V. Ferreira, Micheli S. Sielski, Sébastien Livi, Silvana A. Rocco, Maurício L. Sforça, Jonny Burga-Sánchez, Cristina Pontes Vicente, Lúcia Helena Innocentini Mei
Abstract
wound healing activity tests revealed that when the nanofibers with thrombin-loaded capacity are in contact with the wound, the presence of water in the skin or blood catalyzes the degradation of the membranes, thus releasing thrombin. Thrombin then accelerates the wound clotting process. In contrast to other hemostatic materials, PEO/thrombin nanofibers do not require mechanical removal after application, and the viscoelastic nature of such biomaterials enables their conformation to a variety of wound topographies. Remarkably, PEO/thrombin membranes are promising functional materials and their use is a powerful strategy for hemostatic treatment, ranging from simple first aid and sealing to a wound to small surgical procedures.