The pH-Responsive Transcription Factors YlRim101 and Mhy1 Regulate Alkaline pH-Induced Filamentation in the Dimorphic Yeast Yarrowia lipolytica
Tao Shu, Xinyu He, Jiawen Chen, Yi‐Sheng Mao, Xiang‐Dong Gao
Abstract
Our results show that the transcription factor YlRim101 and the Msn2/Msn4-like transcription factor Mhy1 are the major regulators that promote filamentation at alkaline pH. They control the expression of a number of cell wall protein genes important for cell wall organization and filamentation. Our results suggest that the Rim101/PacC homologs play a conserved role in pH-regulated filamentation in dimorphic fungi.
Topics & Concepts
YarrowiaYeastFilamentationTranscription factorBiochemistryChemistryMicrobiologyBiologyGeneLaserOpticsPhysicsMicrobial Metabolic Engineering and BioproductionFungal and yeast genetics researchRNA and protein synthesis mechanisms