Faropenem reacts with serine and metallo-β-lactamases to give multiple products
Anka Lucic, Philip Hinchliffe, Tika R. Malla, Catherine L. Tooke, Jürgen Brem, Karina Calvopiña, Christopher T. Lohans, Patrick Rabe, M.A. McDonough, Timothy W. Armistead, Allen M. Orville, James Spencer, Christopher J. Schofield
Topics & Concepts
ChemistryImineStereochemistryRing (chemistry)CarbapenemSerine hydrolaseTetrahydrofuranBeta-Lactamase InhibitorsEnamineHydrolysisBicyclic moleculeSubstrate (aquarium)SerineAntibioticsCatalysisEnzymeOrganic chemistryBiochemistrySolventGeologyOceanographyAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatmentAntibiotics Pharmacokinetics and Efficacy