HIV-1 Vpu Promotes Phagocytosis of Infected CD4 <sup>+</sup> T Cells by Macrophages through Downregulation of CD47
Lijun Cong, Scott Sugden, Pascal Leclair, Chinten James Lim, Tram N. Q. Pham, Éric A. Cohen
Abstract
Macrophages play critical roles in human immunodeficiency virus (HIV) transmission, viral spread early in infection, and as a reservoir of virus. Selective capture and engulfment of HIV-1-infected T cells was shown to drive efficient macrophage infection, suggesting that this mechanism represents an important mode of infection notably for weakly macrophage-tropic T/F viruses.
Topics & Concepts
CD47PhagocytosisBiologyCell biologyVirologyMacrophageImmune systemCellTetherinDownregulation and upregulationVirusMicrobiologyViral replicationImmunologyGeneIn vitroBiochemistryGeneticsPhagocytosis and Immune RegulationHIV Research and TreatmentComplement system in diseases