Recent Advances in Resveratrol Derivatives: Structural Modifications and Biological Activities
Xiaohan Liu, Jian Pei, Jiahui Li, Huiyu Zhu, Xiaoyu Zheng, Xingxing Zhang, Ban‐Feng Ruan, Liuzeng Chen
Abstract
Resveratrol, a naturally occurring phenolic stilbene molecule, has been intensively researched for its anti-inflammatory, anticancer, antioxidant, antibacterial, and neuroprotective properties. However, due to its limited absorption and probable hepatotoxicity, it is difficult to employ directly as a medication, limiting its therapeutic applicability. Over the last five years, numerous structural changes in resveratrol have been widely studied, resulting in considerable improvements in pharmacological activity and drug availability. This work reviews the biological activities and structure-activity relationships (SARs) of resveratrol derivatives, with the goal of providing useful insights for the discovery of new resveratrol derivatives.