Anti-Biofilm Strategies: A Focused Review on Innovative Approaches
Antonella Iaconis, Laura Maria De Plano, Antonella Caccamo, Domenico Franco, Sabrina Conoci
Abstract
Biofilm (BF) can give rise to systemic infections, prolonged hospitalization times, and, in the worst case, death. This review aims to provide an overview of recent strategies for the prevention and destruction of pathogenic BFs. First, the main phases of the life cycle of BF and maturation will be described to identify potential targets for anti-BF approaches. Then, an approach acting on bacterial adhesion, quorum sensing (QS), and the extracellular polymeric substance (EPS) matrix will be introduced and discussed. Finally, bacteriophage-mediated strategies will be presented as innovative approaches against BF inhibition/destruction.
Topics & Concepts
Quorum sensingBiofilmAdhesionExtracellular polymeric substanceMicrobiologyNanotechnologyBiochemical engineeringComputer scienceChemistryBiologyBacteriaMaterials scienceEngineeringOrganic chemistryGeneticsBacterial biofilms and quorum sensingBacteriophages and microbial interactionsBiosensors and Analytical Detection