CzcR Is Essential for Swimming Motility in Pseudomonas aeruginosa during Zinc Stress
Zhiqing Liu, Zirui Xu, Zirui Xu, Shuzhen Chen, Jiahui Huang, Ting Li, Cheng Duan, Lian‐Hui Zhang, Zeling Xu, Zeling Xu
Abstract
The fitness of bacterial cells depends largely on their ability to sense and respond quickly to the changing environments. P. aeruginosa expresses a great number of signal sensing and transduction systems that enable the pathogen to grow and survive under diverse stress conditions and cause serious infections at different sites in many hosts. In addition to the previously characterized functions to regulate metal homeostasis, quorum sensing activity, and antibiotic resistance, here we report that CzcR is a novel regulator essential for flagellar gene expression and swimming motility in P. aeruginosa during Zn 2+ stress.
Topics & Concepts
Pseudomonas aeruginosaOperonMotilityQuorum sensingBiologyGeneBiofilmRegulation of gene expressionMicrobiologyCell biologyGene expressionTwo-component regulatory systemGeneticsBacteriaVirulenceEscherichia coliMutantBacterial biofilms and quorum sensingVibrio bacteria research studiesBacterial Genetics and Biotechnology