Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion
Hesheng Ou, Hongli Teng, Yuwang Qin, Xuelan Luo, Peng Yang, Wenyu Zhang, Wei Chen, Dongning Lv, Huamin Tang
Abstract
exploration. I/R-induced rats presented higher TXNIP levels and lower miR-150-5p levels, along with increased cardiomyocyte apoptosis. miR-150-5p in MSCs was transferred through EVs to cardiomyocytes, leading to suppressed myocardial remodeling, as reflected by smaller MIS and CVF and suppressed cardiomyocyte apoptosis. I/R-treated rats injected with MSCs-derived EVs containing miR-150-5p showed a reduction in myocardial remodeling associated with the downregulation of TXNIP, which may be clinically applicable for treatment of I/R.
Topics & Concepts
Mesenchymal stem cellExtracellular vesiclesCell biologymicroRNAMicrovesiclesExtracellularIschemiaStem cellExosomeChemistryReperfusion injuryExtracellular vesicleBiologyMedicineBiochemistryCardiologyGeneExtracellular vesicles in diseaseCardiovascular Disease and AdiposityMicroRNA in disease regulation