HD-ALP fluorescent probe: a high-sensitivity tool for alkaline phosphatase imaging and preclinical diagnosis in three ovarian cancer models
Yingxian Shi, Ruirui Dong, Huan Huang, Gaoying Wang, Jianyi Gao, Kai Wang, Ting Zhang
Abstract
imaging, HD-ALP could effectively reflect the decrease in the fluorescence signal after the addition of ALP inhibitors. By integrating ALP detection, which utilizes the HD-ALP fluorescence mode, with traditional methods like immunohistochemistry staining and serum biomarker detection, potential strategies for more accurate diagnosis of OC may be developed for preclinical trials in the future. According to the research, this is also one of the few developments of fluorescence detection tools for measuring ALP levels in ovarian cancer models.
Topics & Concepts
Alkaline phosphataseOvarian cancerMalignancyCancerPathogenesisMedicineCancer researchInternal medicinePathologyOncologyBiologyBiochemistryEnzymeAlkaline Phosphatase Research StudiesVitamin D Research StudiesParathyroid Disorders and Treatments