Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell
Zhikun Yang, Yue Cai, Shen Mao, Qihao Wu, Mengdi Zhu, Xiaoji Cao, Bin Wei, Jin‐Miao Tian, Xiaoze Bao, Xinyi Ye, Jianwei Chen, Sijia Wang, Yanlei Yu, Huawei Zhang, Xuanrong Sun, Zi‐Ning Cui, Yasheng Li, Hong Wang, Hong Wang
Topics & Concepts
ChemistryPharmacophoreP-glycoproteinEffluxBenzamideMultiple drug resistanceLead compoundWestern blotBenzimidazoleCarboxamideDocking (animal)PharmacologyStereochemistryBiochemistryIn vitroAntibioticsBiologyGeneOrganic chemistryMedicineNursingDrug Transport and Resistance MechanismsCancer therapeutics and mechanismsHIV/AIDS drug development and treatment