Rh(III)-Catalyzed Double C–H Functionalization of Indoles with Cyclopropenones via Sequential C–H/C–C/C–H Bond Activation
Yanbo Zhang, Bin-Shi Li, Guojie Xu, Wei Sun, Meng Sun
Abstract
An unprecedented Rh(III)-catalyzed double C–H functionalization of indoles with cyclopropenones via sequential C–H/C–C/C–H bond activation has been developed. This procedure represents the first example for assembling of cyclopenta[ b ]indoles utilizing cyclopropenones as 3C synthons. This powerful approach shows excellent chemo- and regioselectivity, wide functional group tolerance, and good reaction yields.
Topics & Concepts
ChemistryCatalysisSurface modificationMedicinal chemistryDouble bondStereochemistryPolymer chemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Alkyne Reactions