Rh(<scp>iii</scp>)-Catalyzed and synergistic dual directing group-enabled redox-neutral [3+3] annulation of <i>N</i>-phenoxyacetamides with α-allenols
Fangyuan Chen, Junyuan Tang, Yinhui Wei, Jingyuan Tian, Hui Gao, Wei Yi, Zhi Zhou
Abstract
an unusual [3+3] annulation. This transformation features good functional group tolerance, specific regio-/chemoselectivity and potential synthetic utility. Mechanistic studies reveal that synergistic coordination modes between the dual directing groups (-ONHAc and -OH) and the rhodium metal center account for the observed exclusive selectivity.
Topics & Concepts
AnnulationRedoxChemistryCatalysisDual (grammatical number)Combinatorial chemistryDual roleGroup (periodic table)Medicinal chemistryStereochemistryOrganic chemistryLiteratureArtCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCatalytic Cross-Coupling Reactions