Lincosamide Antibiotics: Structure, Activity, and Biosynthesis
Takahiro Mori, Ikuro Abe, Ikuro Abe
Abstract
Lincosamides are naturally occurring antibiotics isolated from Streptomyces sp. Currently, lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to their unique structures and remarkable biological activities, derivatizations of lincosamides via semi-synthesis and biosynthetic studies have been reported. This review summarizes the structures and biological activities of lincosamides, and the recent studies of lincosamide biosynthetic enzymes.
Topics & Concepts
BiosynthesisAntibioticsChemistryBiochemistryComputational biologyMicrobiologyBiologyGeneCarbohydrate Chemistry and SynthesisCancer therapeutics and mechanismsPhenothiazines and Benzothiazines Synthesis and Activities