Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases
Alyssa C. Walker, Rohan Bhargava, Michael Bucher, Yoan M Argote, Amanda S. Brust, Daniel M. Czyż
Abstract
activates the heat shock response, revealing an unexpected discovery of a microbial influence on host proteostasis. Insight into how individual bacteria affect PCD proteins could open new strategies for prevention and treatment by altering the abundance of microbes.
Topics & Concepts
DiseaseBiologyPathogenesisBacteriaParkinson's diseaseProtein aggregationImmunologyCell biologyMedicineGeneticsPathologyAlzheimer's disease research and treatmentsNeurological diseases and metabolismGut microbiota and health