Characterization of the Sterol 24-C-Methyltransferase Genes Reveals a Network of Alternative Sterol Biosynthetic Pathways in <i>Mucor lusitanicus</i>
Kitti Bauer, Bence Rafael, Bernadett Vágó, Sándor Kiss-Vetráb, Anna Molnár, Csilla Szebenyi, Mónika Varga, András Szekeres, Csaba Vágvölgyi, Tamás Papp, Gábor Nagy
Abstract
The fungal membrane contains ergosterol instead of cholesterol, which offers a specific point of attack for the defense against pathogenic fungi. Indeed, most antifungal agents target ergosterol or its biosynthesis.
Topics & Concepts
SterolBiologyGeneMethyltransferaseGeneticsMucorBiochemistryEvolutionary biologyCholesterolMethylationAspergillusFungal Biology and ApplicationsMicrobial Natural Products and BiosynthesisPolysaccharides and Plant Cell Walls