Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing
Benedetta Artegiani, Delilah Hendriks, Joep Beumer, Rutger N.U. Kok, Xuan Zheng, Indi P. Joore, Susana M. Chuva de Sousa Lopes, Jeroen S. van Zon, Sander J. Tans, Hans Clevers
Topics & Concepts
CRISPRGenome editingOrganoidCas9Gene knockinComputational biologyBiologyGenomeCell biologyGenome engineeringGeneticsGeneCRISPR and Genetic EngineeringPluripotent Stem Cells ResearchChromosomal and Genetic Variations