Engineering CAR-T cells for solid tumors: bispecific antigen targeting, tumor microenvironment modulation, and toxicity control
Tanvi Premchandani, Mohammad Qutub, Amol Tatode, Milind Umekar, Jayshree Taksande, Ujban Hussain, Sameer R. Khidkikar
Topics & Concepts
Chimeric antigen receptorImmunogenicityTumor microenvironmentCancer researchAntigenImmunotherapyChemokineAntigen processingCytokineT cellBispecific antibodyChemistryImmunologyChemokine receptorMedicineComputational biologyImmune systemAntigen presentationTumor antigenTLR3Cytokine release syndromeCAR-T cell therapy researchNanowire Synthesis and ApplicationsNanofabrication and Lithography Techniques