Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems
Hung V.‐T. Nguyen, Alexandre Detappe, Peter Harvey, Nolan M. Gallagher, C. Mathieu, Michael P. Agius, Oksana Zavidij, Wencong Wang, Yivan Jiang, Andrzej Rajca, Alan Jasanoff, Irene M. Ghobrial, P. Peter Ghoroghchian, Jeremiah A. Johnson
Abstract
Pro-organic radical contrast agents (pro-ORCAs) that enable real-time monitoring of doxorubicin prodrug activation <italic>in vitro</italic> and <italic>in vivo</italic> are prepared through brush-first ring-opening metathesis polymerization (ROMP).
Topics & Concepts
Contrast (vision)ChemistryDrugPharmacologyMedicineComputer scienceArtificial intelligenceLanthanide and Transition Metal ComplexesElectron Spin Resonance StudiesAdvanced MRI Techniques and Applications