Exploring the antitumor potential of novel quinoline derivatives <i>via</i> tubulin polymerization inhibition in breast cancer; design, synthesis and molecular docking
Heba Abdelmegeed, Lina M. A. Abdel Ghany, Amira Youssef, Abd-Allah S. El-Etrawy, Noha Ryad
Abstract
value of 17 ± 0.3 μM. The β-tubulin mRNA levels were notably reduced in MDA-MB-231 cells treated with compound 4c which is similar to the effect observed with colchicine treatment. Docking studies revealed that compound 4c interacted well with crucial amino acids in the active site.
Topics & Concepts
QuinolineTubulinChemistryColchicineCombinatorial chemistryMicrotubuleDocking (animal)StereochemistryMolecular modelOrganic chemistryBiologyCell biologyMedicineNursingGeneticsSynthesis and biological activitySynthesis and Biological EvaluationSynthesis of heterocyclic compounds