Pd(<scp>ii</scp>)/diphosphine/curcumin complexes as potential anticancer agents
Jocely L. Dutra, João Honorato, Angélica E. Graminha, Carlos André Ferreira Moraes, Kléber T. de Oliveira, Márcia R. Cominetti, E.E. Castellano, Alzir A. Batista
Abstract
values) against the ovarian cell lines. Complex A1 was 23 and 22-fold more cytotoxic than cisplatin, against the A2780 and A2780cis cells, respectively. The complex A1 was studied on A2780cis cells and it was found that this complex inhibits colony formation and induces cell cycle arrest in the sub-G1 phase in a concentration-dependent manner and leads to cell death by apoptosis. The DCFDA assay revealed a potent ROS induction for complex A1.
Topics & Concepts
CytotoxicityCurcuminIn vitroChemistryPalladiumCombinatorial chemistryCancer researchStereochemistryBiochemistryBiologyCatalysisMetal complexes synthesis and propertiesSynthesis and Characterization of Heterocyclic CompoundsSynthesis of Tetrazole Derivatives