An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement
Guilian Tian, May Hui, Desiree Macchia, Pieter Derdeyn, Alexandra Rogers, Elizabeth Hubbard, Chengfeng Liu, José Vásquez, Lara Taniguchi, Katrina Bartas, Sean Carroll, Kevin T. Beier
Abstract
→amygdala cells are strongly activated after a challenge exposure to cocaine and that activity in these cells is necessary and sufficient for reinstatement of cocaine place preference.
Topics & Concepts
AmygdalaExtended amygdalaVentral tegmental areaStria terminalisNeuroscienceCentral nucleus of the amygdalaNucleus accumbensMidbrainConditioned place preferencePsychologyDopamineSensitizationInhibitory postsynaptic potentialCentral nervous systemDopaminergicNeurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and SignalingMemory and Neural Mechanisms