More Is Not Always Better—the Double-Headed Role of Fibronectin in Staphylococcus aureus Host Cell Invasion
Silke Niemann, Minh‐Thu Nguyen, Johannes A. Eble, Achmet Imam Chasan, Maria Mrakovcic, Ralph T. Böttcher, Klaus T. Preissner, Steffen Roßlenbroich, Georg Peters, Mathias Herrmann
Abstract
Traditionally, Staphylococcus aureus has been considered an extracellular pathogen. However, among other factors, the frequent failure of antimicrobial therapy and the ability of the pathogen to cause recurrent disease have established the concept of eukaryotic invasion of the pathogen, thereby evading the host’s immune system.
Topics & Concepts
FibronectinInternalizationCell biologyStaphylococcus aureusMicrobiologyIntegrinExtracellularPhagocytosisChemistryBiologyCellExtracellular matrixBacteriaBiochemistryGeneticsCell Adhesion Molecules ResearchAntimicrobial Resistance in StaphylococcusNeutrophil, Myeloperoxidase and Oxidative Mechanisms