Mass spectrometry techniques for imaging and detection of metallodrugs
Sarah Theiner, Anna Schoeberl, Andreas Schweikert, Bernhard K. Keppler, Gunda Koellensperger
Abstract
Undoubtedly, metallomic approaches based on mass spectrometry have evolved into essential tools supporting the drug development of novel metal-based anticancer drugs. This article will comment on the state-of-the-art instrumentation and highlight some of the recent analytical advances beyond routine, especially focusing on the latest developments in inductively coupled plasma-mass spectrometry (ICP-MS). Mass spectrometry-based bioimaging and single-cell methods will be presented, paving the way to exciting investigations of metal-based anticancer drugs in heterogeneous and structurally, as well as functionally complex solid tumor tissues.
Topics & Concepts
Mass spectrometryInductively coupled plasma mass spectrometryMass spectrometry imagingChemistryNanotechnologyChromatographyMaterials scienceAdvanced biosensing and bioanalysis techniquesMass Spectrometry Techniques and ApplicationsElectron and X-Ray Spectroscopy Techniques