CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells
Grant R. Campbell, Jia Zhuang, Gang Zhang, Igor Landa, Luke J. Kubiatowicz, Diana Dehaini, Ronnie H. Fang, Liangfang Zhang, Stephen A. Spector
Abstract
DIABLO/SMAC mimetic loaded TNP have the potential to be used as therapeutic agents to neutralize cell-free HIV-1 and to kill specifically HIV-1-infected cells as part of an HIV-1 cure strategy.
Topics & Concepts
Human immunodeficiency virus (HIV)Cytotoxic T cellBystander effectEpitopeAutophagyVirologyApoptosisAntibodyBiologyChemistryIn vitroImmunologyBiochemistryHIV Research and TreatmentImmune Cell Function and InteractionHIV/AIDS Research and Interventions