Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase
Sang Jun Han, Jee In Kim, Joshua H. Lipschutz, Kwon Moo Park
Abstract
Recent emerging evidence has demonstrated that changes in primary cilia are associated with various genetic and non-genetic diseases, such as autosomal dominant polycystic kidney disease, obesity, hypertension, and diabetes Moreover, recent reports revealed that the length of primary cilia reflects pathophysiologi-
Topics & Concepts
CiliumCell biologyMAPK/ERK pathwayCystathionine gamma-lyaseSodium hydrosulfideCiliogenesisSignal transductionChemistryBiologyBiochemistryCystathionine beta synthaseHydrogen sulfideEnzymeOrganic chemistryCysteineSulfurGenetic and Kidney Cyst DiseasesSulfur Compounds in BiologyBiomedical Research and Pathophysiology