Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles
Ali Wang, Xin Xie, Chunli Zhang, Yuanhong Liu
Abstract
A gold-catalyzed oxidative cyclization of alkyne-nitriles using water or alcohol as the external nucleophiles has been developed. The catalytic system, featured with gold and Lewis acid dual catalysis, allows a facile synthesis of functionalized isoquinolin-1(2H)-ones and 1-alkoxy-isoquinolines with a wide structural diversity.
Topics & Concepts
AlkyneLewis acids and basesCatalysisChemistryOxidative phosphorylationAlcoholAlkoxy groupCombinatorial chemistryOrganic chemistryMedicinal chemistryAlkylBiochemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods