Ad- and AAV8-mediated ABCA1 gene therapy in a murine model with retinal ischemia/reperfusion injuries
Jing Luo, Shengli Wang, Zhenlong Zhou, Yin Zhao
Abstract
protects against RGC apoptosis by partially blocking ANXA1 nuclear translocation. This study puts forth a potential gene treatment strategy to prevent RGC apoptosis in glaucoma.
Topics & Concepts
Annexin A1ABCA1Cell biologyBiologyExtracellularApoptosisMolecular biologyAnnexinBiochemistryGeneTransporterS100 Proteins and AnnexinsGlaucoma and retinal disordersCell Adhesion Molecules Research