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UGT2B10 is the Major UDP-Glucuronosyltransferase 2B Isoform Involved in the Metabolism of Lamotrigine and is Implicated in the Drug-Drug Interaction with Valproic Acid

Lloyd Wei Tat Tang, Kimberly Lapham, Theunis C. Goosen

2024The AAPS Journal17 citationsDOI

Topics & Concepts

Valproic AcidLamotrigineDrugGlucuronidationDrug metabolismGene isoformChemistryPharmacologyBiochemistryMedicineMicrosomeEnzymeEpilepsyPsychiatryGenePharmacological Effects and Toxicity StudiesPharmacogenetics and Drug MetabolismHIV/AIDS drug development and treatment
UGT2B10 is the Major UDP-Glucuronosyltransferase 2B Isoform Involved in the Metabolism of Lamotrigine and is Implicated in the Drug-Drug Interaction with Valproic Acid | Litcius