Development of novel cyanopyridines as PIM-1 kinase inhibitors with potent anti-prostate cancer activity: Synthesis, biological evaluation, nanoparticles formulation and molecular dynamics simulation
Mona H. Ibrahim, Marwa F. Harras, Shaimaa K. Mostafa, Salma M. Mohyeldin, Omkulthom Al kamaly, Najla Altwaijry, Rehab Sabour
Topics & Concepts
ChemistryADMEKinaseCytotoxicityIC50Docking (animal)In silicoLead compoundCancer cellStereochemistryIn vitroBiochemistryCancerInternal medicineMedicineNursingGeneCancer Mechanisms and TherapySynthesis and biological activitySynthesis and bioactivity of alkaloids