Dengue Virus is Hyperendemic in Nigeria from 2009 to 2020: A Contemporary Systematic Review
Anthony Uchenna Emeribe, Idris Nasir Abdullahi, Idongesit Kokoabasi Isong, A O Emeribe, Justin Onyebuchi Nwofe, Bukhari Isah Shuaib, Abubakar Muhammad Gwarzo, Yahaya Usman, Madjid Sadi, Chikodi Modesta Umeozuru, Amos Dangana, Bibiana Nonye Egenti, Mala A. Sainna, Abigaíl Castellano López, Maijiddah Saidu Aminu, Hadiza Yahaya, Silifat Oyewusi
Abstract
BACKROUND: Data on Dengue virus (DENV) infection prevalence, geographic distribution and risk factors are necessary to direct appropriate utilization of existing and emerging control strategies. This study aimed to determine the pooled prevalence, risk factors of DENV infection and the circulating serotypes within Nigeria from January 1, 2009 to December 31, 2020. MATERIALS AND METHODS: Twenty-one studies out of 2,215 available articles were eligible and included for this systematic review. Relevant articles were searched, screened and included in this study according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) criteria. The risk of bias in primary studies was assessed by Cochrane's method. Heterogeneity of pooled prevalence was calculated using the chi-square test on Cochrane's Q statistic, which was quantified by I-square values. The random-effects analyses of proportions were used to determine the pooled prevalence of DENV antibodies, antigen and RNA from eligible studies. RESULTS: <0.05). CONCLUSION: Based on these findings, it can be inferred that Nigeria is hyperendemic for Dengue fever and needs concerted efforts to control its spread within and outside the country.