Direct C–C Bond Cleavage of 1,3-Dicarbonyl Compounds as a Single-Carbon Synthon: Synthesis of 2-Aryl-4-quinolinecarboxylates
You Zhou, Peng Zhao, Li‐Sheng Wang, Xiaoxiao Yu, Chun Huang, Yan‐Dong Wu, An‐Xin Wu
Abstract
A novel [2 + 1 + 3] cyclization reaction for the synthesis of 2-aryl-4-quinolinecarboxylates from aryl methyl ketones, arylamines, and 1,3-dicarbonyl compounds has been established. This metal-free process achieved the C-C bond cleavage of 1,3-dicarbonyl compounds directly as a single-carbon synthon. The reaction is highly efficient and has good substrate compatibility while operating under mild conditions. This method has good practicability and successfully realized the synthesis of bioactive molecules.
Topics & Concepts
SynthonChemistryArylBond cleavageCleavage (geology)Combinatorial chemistryMoleculeOrganic chemistryStereochemistryCatalysisAlkylFracture (geology)Geotechnical engineeringEngineeringCatalytic C–H Functionalization MethodsMulticomponent Synthesis of HeterocyclesSynthesis and Biological Evaluation