ImuA Facilitates SOS Mutagenesis by Inhibiting RecA-Mediated Activity in Myxococcus xanthus
Duohong Sheng, Ye Wang, Zhiwei Jiang, Dongkai Liu, Yue‐zhong Li
Abstract
DnaE2 is responsible for bacterial SOS mutagenesis in nearly one-third of sequenced bacterial strains. However, its mechanism, especially the function of one of its accessory proteins, ImuA, is still unclear. Here, we report that M. xanthus ImuA could affect SOS mutagenesis by inhibiting the recombinase activity of RecA1, which helps to explain the mechanism of DnaE2-dependent TLS and the selection of the two restart pathways to repair the stalled replication fork.
Topics & Concepts
Myxococcus xanthusMutagenesisSOS responseBiologyRecombinaseDNAMutantGeneGeneticsCell biologyRecombinationDNA Repair MechanismsBacterial Genetics and BiotechnologyCRISPR and Genetic Engineering