Brain injury instructs bone marrow cellular lineage destination to reduce neuroinflammation
Samuel Shi, Kaibin Shi, Qiang Liu
Abstract
monocytes, which could be further potentiated by the U.S. Food and Drug Administration-approved β3-adrenergic agonist mirabegron. Our results suggest that brain injury modulates HSC lineage development to curb distal brain inflammation, implicating the bone marrow as a unique niche for self-protective neuroimmune interaction that might be exploited to obtain therapeutic effects.
Topics & Concepts
NeuroinflammationBone marrowLineage (genetic)HaematopoiesisMyeloid cellsMyeloidIntracerebral hemorrhageMedicineStem cellHematopoietic stem cellPathologyNeurosciencePrecursor cellCellImmunologyBiologyCell biologyInflammationInternal medicineGeneGeneticsSubarachnoid hemorrhageIntracerebral and Subarachnoid Hemorrhage ResearchImmune cells in cancerTraumatic Brain Injury and Neurovascular Disturbances