Design and synthesis of luotonin A-derived topoisomerase targeting scaffold with potent antitumor effect and low genotoxicity
Xinwei Li, Shu-Jun Fang, Ying-Ze Li, Li-Qing Qin, Nan‐Ying Chen, Bin Zheng, Dong‐Liang Mo, Gui‐Fa Su, Jun‐Cheng Su, Cheng‐Xue Pan, Cheng‐Xue Pan
Topics & Concepts
TopoisomeraseChemistryGenotoxicityCytotoxicityDNA damageToxicityPharmacologyTopoisomerase inhibitorCarcinogenesisCancer cellCancer researchIn vitroCancerDNABiochemistryBiologyGeneticsOrganic chemistryGeneCancer therapeutics and mechanismsLung Cancer Research StudiesBioactive Compounds and Antitumor Agents