I<sub>2</sub>/NaH<sub>2</sub>PO<sub>2</sub>-mediated deoxyamination of cyclic ethers for the synthesis of <i>N</i>-aryl-substituted azacycles
Ying‐Chih Lin, Dongyang Li, Jingjing Zhang, Zhi Tang, Long Liu, Tianzeng Huang, Chunya Li, Tieqiao Chen
Abstract
We have developed a protocol for efficient synthesis of N -aryl-substituted azacycles from aryl amines and cyclic ethers using I 2 /NaH 2 PO 2 as the mediator.
Topics & Concepts
ChemistryArylMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques