Matrix stiffness-dependent microglia activation in response to inflammatory cues: <i>in situ</i> investigation by scanning electrochemical microscopy
Yulin Liu, Junjie Zhang, Yabei Li, Yuxiang Zhao, Shuake Kuermanbayi, Jian Zhuang, Hua Zhang, Feng Xu, Fei Li
Abstract
and dynamic monitoring of microglia activation state alterations under a mechanical-inflammatory coupled microenvironment using SECM. Our findings shed light on matrix stiffness-dependent activation of microglia in response to an inflammatory microenvironment, providing valuable insights into the mechanisms underlying neuroinflammatory processes in the CNS.
Topics & Concepts
MicrogliaCell biologyLipopolysaccharideExtracellular matrixNeuroinflammationReactive oxygen speciesChemistryMechanotransductionBiophysicsScanning electrochemical microscopyNeuroscienceInflammationBiologyImmunologyElectrochemistryElectrodePhysical chemistryNeuroinflammation and Neurodegeneration MechanismsElectrochemical Analysis and ApplicationsLipid Membrane Structure and Behavior