Physical principles and mechanisms of cell migration
Roberto Alonso-Matilla, Paolo P. Provenzano, David J. Odde
Abstract
Cell migration is critical in processes such as developmental biology, wound healing, immune response, and cancer invasion/metastasis. Understanding its regulation is essential for developing targeted therapies in regenerative medicine, cancer treatment and immune modulation. This review examines cell migration mechanisms, highlighting fundamental physical principles, key molecular components, and cellular behaviors, identifying existing gaps in current knowledge, and suggesting potential directions for future research.
Topics & Concepts
Immune systemMetastasisRegenerative medicineCell migrationCancer metastasisNeuroscienceBiologyCancerCellCell biologyStem cellImmunologyGeneticsCellular Mechanics and InteractionsMicrotubule and mitosis dynamicsAxon Guidance and Neuronal Signaling