DPP7 promotes fatty acid β-oxidation in tumor-associated macrophages and determines immunosuppressive microenvironment in colorectal cancer
Jiang Chang, Yuxu Niu, Shizhao Zhou, Weiying Zhu, Ziqi Zhang, Haidi Xiu, Ke Shang, Qingyang Feng, Ye Wei
Abstract
TAMs may potentiate the efficacy of immunotherapy for CRC.
Topics & Concepts
Cancer researchTumor microenvironmentGene knockdownImmune systemImmunotherapyColorectal cancerMetastasisReprogrammingIn vivoCarnitineFatty acid metabolismChemistryCancer immunotherapyFatty acidLipid metabolismBeta oxidationCancerBiologyCytokineMedicineMetabolomicsPharmacologyFatty acid synthaseEpithelial–mesenchymal transitionNonalcoholic fatty liver diseaseIn vitroFlow cytometryRNA interferenceImmunosuppressionCancer cellFOXP3Cancer, Lipids, and MetabolismCancer, Hypoxia, and MetabolismPeroxisome Proliferator-Activated Receptors