A review of recent advances in anticancer activity and SAR of pyrazole derivatives
Heba A. Hofny, Mamdouh F. A. Mohamed, Heba A. Hassan, Elshimaa M. N. Abdelhafez, Gamal El‐Din A. Abuo‐Rahma
Abstract
The present review serves to highlight the antitumor worth of pyrazole derivatives. Several active pyrazole-based anticancer compounds proposed by a huge number of scientists worldwide are reported. Regarding the development of novel pyrazole-based anticancer agents at a faster tone, there is a need to correlate the latest information with previously available information to understand the situation of this moiety in anticancer drug discovery studies. Herein, different anticancer pyrazoles are classified according to their mode of action at different anticancer targets. The results provided evidence that pyrazole derivatives have potential applications for the treatment of a variety of tumor types. From the study's findings, the structure-activity relationship (SAR) results demonstrated that all the compounds containing substituted pyrazole represent an important scaffold for anticancer activities. Publications in this area are increasing, and therefore, new therapeutic applications involving members of pyrazole derivatives could be discovered in the near future, as many prospects have not been sufficiently studied so far for other targets. In other words, this review provides an overview of the state of knowledge about the structural characteristics of the most recent anticancer pyrazole derivatives and their SAR with various targets. This will allow medicinal chemists to identify promising structures to guide the design and synthesis of more effective and safer anticancer candidates.