Malic Enzyme, not Malate Dehydrogenase, Mainly Oxidizes Malate That Originates from the Tricarboxylic Acid Cycle in Cyanobacteria
Noriaki Katayama, Kaori Iwazumi, Hiromi Suzuki, Takashi Osanai, Shoki Ito
Abstract
as a coenzyme, unlike other cyanobacterial TCA cycle enzymes. Our analyses revealed that another malate oxidation enzyme, the malic enzyme, mainly oxidizes malate that originates from the cyanobacterial TCA cycle. These findings provide better insights into metabolite production using the cyanobacterial TCA cycle. Furthermore, our findings suggest that the enzymes related to the TCA cycle vary from organism to organism and emphasize the importance of analyses to identify the enzymes such as those performed in this study.
Topics & Concepts
Citric acid cycleMalate dehydrogenaseTricarboxylic acidCyanobacteriaMalic acidBiochemistryIsocitrate dehydrogenaseBacteriaMetaboliteChemistryEnzymeMalic enzymeBiologyDehydrogenaseCitric acidGeneticsPhotosynthetic Processes and MechanismsAlgal biology and biofuel productionBiocrusts and Microbial Ecology