Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism
Xiaojiao Zheng, Tianlu Chen, Runqiu Jiang, Aihua Zhao, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lü, Weiping Jia, Changtao Jiang, Wei Jia
Topics & Concepts
Farnesoid X receptorG protein-coupled bile acid receptorGlucose homeostasisBile acidInternal medicineEndocrinologyTauroursodeoxycholic acidBiologyHomeostasisDownregulation and upregulationSecretionReceptorEnteroendocrine cellGlucagon-like peptide-1Diabetes mellitusType 2 diabetesNuclear receptorInsulin resistanceBiochemistryHormoneEndocrine systemUnfolded protein responseMedicineTranscription factorEndoplasmic reticulumGeneDiabetes Treatment and ManagementPancreatic function and diabetesDrug Transport and Resistance Mechanisms