Reversible Stimuli‐Responsive Transmembrane Ion Transport Using Phenylhydrazone‐Based Photoswitches
Manzoor Ahmad, Debashis Mondal, Naveen J. Roy, Thangavel Vijayakanth, Pinaki Talukdar
Abstract
Abstract Phenylhydrazone‐based synthetic receptors are reported as stimuli‐responsive anion transporters. The X‐ray crystallographic studies confirmed the preorganized anion binding E ‐state and closed non‐binding Z ‐state. The detailed ion transport mechanistic studies confirmed Cl − /anion exchange as the primary ion transport process. Their light‐stimulated E ‐to‐ Z isomerization led to a substantial decrease in the ion transport activity across the lipid bilayer membrane. Reversible “OFF” and “ON” activity switching was studied by light and acid stimuli, respectively.
Topics & Concepts
ChemistryIonIsomerizationIon transporterBiophysicsLipid bilayerIon channelTransmembrane proteinMembraneBilayerPhotochemistryReceptorBiochemistryOrganic chemistryCatalysisBiologyMolecular Sensors and Ion DetectionPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics research