Brincidofovir for disease progression due to suspected tecovirimat resistance in association with advanced HIV
Iris Harrison, Kathryn DeSear, Barbara A. Santevecchi, Veena Venugopalan, Kartikeya Cherabuddi, Nicole M. Iovine, Nila Radhakrishnan
Abstract
A man with advanced HIV presented with verrucous plaques 2-3 months after initial mpox infection. He received two courses of tecovirimat without resolution of initial mpox lesions and development of new lesions raising concern for resistance. He was treated with two doses of brincidofovir and demonstrated improvement 6 months later.
Topics & Concepts
MedicineHuman immunodeficiency virus (HIV)DiseaseSexually transmitted diseaseAcquired resistanceSurgeryInternal medicineImmunologyCancerSyphilisPoxvirus research and outbreaksHerpesvirus Infections and TreatmentsBacillus and Francisella bacterial research