A cascaded enzyme-loaded Fe–hemoporfin framework for synergistic sonodynamic-starvation therapy of tumors
Mei Wen, Jiayue Shen, Zhaojie Wang, Honghua Guo, Peng Geng, Nuo Yu, Maoquan Li, Haijun Zhang, Meifang Zhu, Zhigang Chen
Abstract
generation than that of pure FeHF, resulting from the cascaded catalytic reaction from the dual-enzyme system. As observed by magnetic resonance imaging, the intravenously injected FeHF-GOx/CAT was accumulated within tumors. The FeHF-GOx/CAT + US exhibited the highest inhibition effect compared to the FeHF-CAT + US (only SDT) or FeHF-GOx/CAT (only starvation therapy), due to the synergistic effects of SDT and starvation therapy. Therefore, the cascaded dual-enzyme loading strategy can increase the SDT efficiency of FeHF, which may guide further works in the development of efficient nanosonosensitizers.
Topics & Concepts
Sonodynamic therapyStarvationEnzymeCancer therapyCancer researchChemistryCancerBiochemistryMedicineInternal medicineApoptosisNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryIntracranial Aneurysms: Treatment and Complications