Arylacetylenes as two-carbon synthons: synthesis of eight-membered rings <i>via</i> CC bond cleavage
Peng Zhao, Xiaoxiao Yu, You Zhou, Chun Huang, Yan‐Dong Wu, Yanping Zhu, An‐Xin Wu
Abstract
The first synthesis of eight-membered N-containing heterocycles by oxidative bicyclization/ring extension of arylacetylenes and aryl amines has been achieved. This protocol uses arylacetylene as an unusual two-carbon synthon by incorporating the two parts of the cracked C[triple bond, length as m-dash]C bond into the final product, which provides a new method for using arylacetylenes as two-carbon synthons and further enriches C[triple bond, length as m-dash]C bond cleavage methodology. Moreover, this multi-component reaction can provide diverse fused elegant eight-membered N-heterocycles under mild conditions with wide substrate scopes.
Topics & Concepts
SynthonChemistryTriple bondBond cleavageArylCleavage (geology)Ring (chemistry)Carbon fibersSubstrate (aquarium)Combinatorial chemistrySingle bondStereochemistryMedicinal chemistryDouble bondOrganic chemistryMaterials scienceGroup (periodic table)CatalysisComposite materialOceanographyGeologyFracture (geology)AlkylComposite numberCatalytic C–H Functionalization MethodsChemical Synthesis and AnalysisCatalytic Cross-Coupling Reactions