Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy
Zhengrong Lin, Long Meng, Junjie Zou, Wei Zhou, Xiaowei Huang, Shan Yi. Xue, Tianyuan Bian, Tifei Yuan, Lili Niu, Yanwu Guo, Hairong Zheng
Abstract
Herein, we demonstrated for the first time that low-intensity pulsed ultrasound improves electrophysiological activities and behavioral outcomes in a non-human primate model of epilepsy and suppresses epileptiform activities of neurons from human epileptic slices. The study provides evidence for the potential clinical use of non-invasive low-intensity pulsed ultrasound stimulation for epilepsy treatment.
Topics & Concepts
NeuromodulationEpilepsyNeuroscienceMedicineUltrasonic sensorPsychologyCentral nervous systemRadiologyUltrasound and Hyperthermia ApplicationsVagus Nerve Stimulation ResearchNeuroscience and Neural Engineering