Electrochemical Selenized Reaction of <i>N</i>-Arylbicyclo[1.1.0]butane-1-carboxamides: Access to 3-(Arylselanyl)spiro[cyclobutane-1,3′-indolin]-2′-one Derivatives
Jiyao Liu, Yuliang Qian, Haicheng Zhao, Yun Liu, Zhenglong Qin, Zifeng Zhang, Liangce Rong
Abstract
-arylbicyclo [1.1.0]butane-1-carboxamides with diselenide for the synthesis of polycyclic indoline derivatives is developed under electrochemical conditions. The synthesis is achieved by the bicyclo[1.1.0]butane strain-release reaction and intramolecular cyclization process. In addition, this approach features a wide range of substrates, good group tolerance, shorter reaction time, and mild conditions.
Topics & Concepts
CyclobutaneButaneElectrochemistryChemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisPhysical chemistryElectrodeRing (chemistry)Radical Photochemical ReactionsSulfur-Based Synthesis TechniquesElectrochemical Analysis and Applications